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December 2014

Volume 1  Issue 2

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Editorial
A Difficult Task on Malaria Control

Dos-Santos AL*

Malaria is one most devastating infectious diseases in the world. In 2012, 135 - 287 million people were infected and 473,000 – 789,000 people died from malaria worldwide. Data from WHO show that 90% of these deaths occurred in sub-Saharan Africa; 77% were children under 5 years old.

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Editorial
Toxoplasma Gondii: The Mind-Control Parasite

Claudia F. Dick*

Toxoplasma gondii is an extremely widespread protozoan parasite, with a prevalence of 20-70% in USA. This high prevalence is attributable in part to the HIV pandemic: neurotoxoplasmosis is the most frequent oportunistic infection and the most common cause of brain focal injuries in AIDS patients.                                                                                                                                                                                                                               Full text  Download PDF        ____________________________________________________________________________________________________________

Case Report
Osteonecrosis of the Jaws Induced by Antiresorptive Drugs: A Clinical Case Report

Eduardo Cláudio Lopes de Chaves e Mello Dias*, KhalilaChequer Cotrim and Eduardo Seixas Cardoso

Antiresorptive drugs, such as bisphosphonates and the RANK-ligand inhibitor denosumab, are potent inhibitors of bone remodeling used to treat diseases affecting bone metabolism. Despite their wide use as therapeutic agents to reduce morbidity in cancer patients and to treat postmenopausal osteoporosis, in recent years, there have been reports of osteonecrosis of the jaws caused by bisphosphonate drugs and, even more recently, associated with RANK-ligand inhibitors (denosumab).

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Review Article
Overview of Graft-Versus-Host Disease with Emphasis on the Pathogenesis of Autologous Graft-Versus-Host Disease

Benjamin H. Durham*, M.D, Mingyi Chen, M.D, Ph.D

Graft-versus-host disease is a common complication following allogeneic hematopoietic stem cell transplantation that manifests with injury to the gastrointestinal mucosa, skin, and liver. A clinically and histologically indistinguishable graft-versus-host-disease-like syndrome has been described following autologous stem cell transplantation. The current pathogenesis is attributed to the lymphoablative preparative regimen.

                                                                                                                                                                                                                               Full text   Download PDF

 

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Research Article
Optimization of Assisted Reproduction Technologies in Patients with Hereditary Thrombophilia and Recurrent IVF Failures

Podzolkova NM MD Professor, Rogovskaya SI MD Professor, Koloda Yu A . MD Ph.D*, Danshina VA MD

According to the numerous studies every sixth couple in the world is faced with the problem of infertility. However despite the rapid development of reproductive medicine the efficiency of ART programs remains stable and approximately 30% of couples have repeated in vitro fertilization (IVF) failures .

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Research Article
Coagulase-Negative Staphylococci from Hospital-Associated Infections Harboring Virulence Genes

Wagner Luis Mendes de Oliveira, Ewerton Lucena Ferreira, Eduarda Vanessa Cavalcante Mangueira, Marinalda Anselmo Vilela, Alzira Maria Paiva de Almeida, Nilma Cintra Leal*

Coagulase-negative staphylococci (CoNS) are frequently isolated from hospital infections associated with biofilm formation on implanted medical devices. However, the toxigenic potential of CoNS is not yet fully understood. Here we report the presence of putative virulence-associated genes usually known for Staphylococcus aureus in CoNS isolates from hospital-associated infections in Recife, Pernambuco, Brazil.

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